Human Adipose Tissue Atlas v1.0 — Myeloid cells

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Cell Metadata

CD14⁺S100A8/9⁺ Monocytes

Ontology Term: monocyteCL:0000576
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: inflammatory monocyte
Category Class of which the cell type is a subclass.: monocyteCL:0000576
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FCN1, S100A8, S100A9
Canonical Marker Genes: FCN1, S100A8, S100A9
Rationale: FCN1 (ficolin-1) is a pattern recognition molecule with enriched expression in monocytes broadly. S100A8 and S100A9 (calprotectin subunits) show highly enriched expression in this specific subset, marking an inflammatory monocyte state associated with innate immune activation. Together these markers identify a transcriptionally distinct CD14⁺S100A8/9⁺ monocyte population and distinguish them from classical and non-classical monocyte subsets.
Rationale DOI: 10.2119/molmed.2011.00144

Ontology Term: monocyteCL:0000576
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: inflammatory monocyte
Category Class of which the cell type is a subclass.: monocyteCL:0000576
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FCN1, S100A8, S100A9
Canonical Marker Genes: FCN1, S100A8, S100A9
Rationale: FCN1 (ficolin-1) is a pattern recognition molecule with enriched expression in monocytes broadly. S100A8 and S100A9 (calprotectin subunits) show highly enriched expression in this specific subset, marking an inflammatory monocyte state associated with innate immune activation. Together these markers identify a transcriptionally distinct CD14⁺S100A8/9⁺ monocyte population and distinguish them from classical and non-classical monocyte subsets.
Rationale DOI: 10.2119/molmed.2011.00144