Human Adipose Tissue Atlas v1.0 — Myeloid cells

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Cell Metadata

Neutrophils

Ontology Term: neutrophilCL:0000775
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: PMN, polymorphonuclear leucocyte, polynuclear neutrophilic leukocyte, neutrophil leukocyte, polymorphonuclear leukocyte
Category Class of which the cell type is a subclass.: myeloid cellCL:0000763
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: S100A12, S100A9, CSF3R, CXCR2, FCGR3B
Canonical Marker Genes: S100A12, S100A9, CSF3R, CXCR2, FCGR3B
Rationale: S100A12 and S100A9 are calcium-binding proteins highly expressed in neutrophils and reflect their inflammatory state. CSF3R (CD114, G-CSF receptor) is a surface receptor involved in neutrophil development and survival. CXCR2 is a chemokine receptor mediating neutrophil recruitment to sites of inflammation, and FCGR3B (CD16b) is a neutrophil-specific isoform of CD16 distinguishing neutrophils from NK cells and monocytes that express FCGR3A. Together these markers reliably identify neutrophils and distinguish them from other myeloid cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9 10.1016/s1074-7613(01)00150-9 10.1097/MOH.0000000000000476

Ontology Term: neutrophilCL:0000775
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: PMN, polymorphonuclear leucocyte, polynuclear neutrophilic leukocyte, neutrophil leukocyte, polymorphonuclear leukocyte
Category Class of which the cell type is a subclass.: myeloid cellCL:0000763
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: S100A12, S100A9, CSF3R, CXCR2, FCGR3B
Canonical Marker Genes: S100A12, S100A9, CSF3R, CXCR2, FCGR3B
Rationale: S100A12 and S100A9 are calcium-binding proteins highly expressed in neutrophils and reflect their inflammatory state. CSF3R (CD114, G-CSF receptor) is a surface receptor involved in neutrophil development and survival. CXCR2 is a chemokine receptor mediating neutrophil recruitment to sites of inflammation, and FCGR3B (CD16b) is a neutrophil-specific isoform of CD16 distinguishing neutrophils from NK cells and monocytes that express FCGR3A. Together these markers reliably identify neutrophils and distinguish them from other myeloid cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9 10.1016/s1074-7613(01)00150-9 10.1097/MOH.0000000000000476