Human Adipose Tissue Atlas v1.0 — Myeloid cells

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Cell Metadata

PVMs

Ontology Term: perivascular macrophageCL:0000881
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: pvMΦ
Category Class of which the cell type is a subclass.: macrophageCL:0000235
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MRC1, F13A1, LYVE1, SELENOP, C1QA
Canonical Marker Genes: MRC1, F13A1, LYVE1, SELENOP, C1QA
Rationale: MRC1 (CD206) and F13A1 are general macrophage markers broadly expressed across tissue-resident macrophage populations. LYVE1, SELENOP (selenoprotein P), and C1QA show enriched expression in perivascular macrophages specifically, with LYVE1 marking macrophages associated with the perivascular niche. Together these markers identify perivascular macrophages (PVMs) and distinguish them from other macrophage subpopulations including LAMs.
Rationale DOI: 10.1038/s42255-025-01296-9

Main

Cell Metadata

Ontology Term: perivascular macrophageCL:0000881
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: pvMΦ
Category Class of which the cell type is a subclass.: macrophageCL:0000235
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MRC1, F13A1, LYVE1, SELENOP, C1QA
Canonical Marker Genes: MRC1, F13A1, LYVE1, SELENOP, C1QA
Rationale: MRC1 (CD206) and F13A1 are general macrophage markers broadly expressed across tissue-resident macrophage populations. LYVE1, SELENOP (selenoprotein P), and C1QA show enriched expression in perivascular macrophages specifically, with LYVE1 marking macrophages associated with the perivascular niche. Together these markers identify perivascular macrophages (PVMs) and distinguish them from other macrophage subpopulations including LAMs.
Rationale DOI: 10.1038/s42255-025-01296-9