Human Adipose Tissue Atlas v1.0 — Myeloid cells

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Cell Metadata

LAMs

Ontology Term: lipid-associated macrophageCL:4033086
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LAM
Category Class of which the cell type is a subclass.: macrophageCL:0000235
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MRC1, F13A1, CD9, TREM2, LPL
Canonical Marker Genes: MRC1, F13A1, CD9, TREM2, LPL
Rationale: MRC1 (CD206) and F13A1 are general macrophage markers broadly expressed across tissue-resident macrophage populations. CD9, TREM2, and LPL (lipoprotein lipase) show enriched expression in lipid-associated macrophages specifically, with TREM2 being a receptor involved in lipid sensing and metabolism. Together these markers identify lipid-associated macrophages (LAMs) and distinguish them from other macrophage subpopulations.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: lipid-associated macrophageCL:4033086
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LAM
Category Class of which the cell type is a subclass.: macrophageCL:0000235
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MRC1, F13A1, CD9, TREM2, LPL
Canonical Marker Genes: MRC1, F13A1, CD9, TREM2, LPL
Rationale: MRC1 (CD206) and F13A1 are general macrophage markers broadly expressed across tissue-resident macrophage populations. CD9, TREM2, and LPL (lipoprotein lipase) show enriched expression in lipid-associated macrophages specifically, with TREM2 being a receptor involved in lipid sensing and metabolism. Together these markers identify lipid-associated macrophages (LAMs) and distinguish them from other macrophage subpopulations.
Rationale DOI: 10.1038/s42255-025-01296-9