Human Adipose Tissue Atlas v1.0 — Myeloid cells

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Cell Metadata

Inflammatory macrophages

Ontology Term: M1 macrophageCL:0000863
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: inflammatory macrophage, classically activated macrophage
Category Class of which the cell type is a subclass.: macrophageCL:0000235
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MRC1, F13A1, CCL3L1, TNF, CXCL3
Canonical Marker Genes: MRC1, F13A1, CCL3L1, TNF, CXCL3
Rationale: MRC1 (CD206) and F13A1 are general macrophage markers broadly expressed across tissue-resident macrophage populations. CCL3L1, TNF (tumor necrosis factor), and CXCL3 show enriched expression in inflammatory macrophages, reflecting a pro-inflammatory activation state rather than a fixed macrophage subset identity. Together these markers identify a transcriptionally distinct inflammatory macrophage population and distinguish them from resident macrophage subpopulations such as LAMs and PVMs.
Rationale DOI: 10.1038/s42255-025-01296-9

Ontology Term: M1 macrophageCL:0000863
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: inflammatory macrophage, classically activated macrophage
Category Class of which the cell type is a subclass.: macrophageCL:0000235
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MRC1, F13A1, CCL3L1, TNF, CXCL3
Canonical Marker Genes: MRC1, F13A1, CCL3L1, TNF, CXCL3
Rationale: MRC1 (CD206) and F13A1 are general macrophage markers broadly expressed across tissue-resident macrophage populations. CCL3L1, TNF (tumor necrosis factor), and CXCL3 show enriched expression in inflammatory macrophages, reflecting a pro-inflammatory activation state rather than a fixed macrophage subset identity. Together these markers identify a transcriptionally distinct inflammatory macrophage population and distinguish them from resident macrophage subpopulations such as LAMs and PVMs.
Rationale DOI: 10.1038/s42255-025-01296-9