Human Adipose Tissue Atlas v1.0 — Myeloid cells

Main

Cell Metadata

Mast cells

Ontology Term: mast cellCL:0000097
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: tissue basophil, mastocyte, histaminocyte, labrocyte
Category Class of which the cell type is a subclass.: myeloid cellCL:0000763
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: KIT, CPA3
Canonical Marker Genes: KIT, CPA3
Rationale: KIT (CD117) is a receptor tyrosine kinase broadly used to identify mast cells across tissues. CPA3 (carboxypeptidase A3) is a mast cell-specific serine protease stored in secretory granules. Together these markers reliably identify mast cells and distinguish them from other immune cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Level 2 cell type labels (represents broad clusters most studies tend to identify).
Annotation Method: manual

Main

Cell Metadata

Ontology Term: mast cellCL:0000097
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: tissue basophil, mastocyte, histaminocyte, labrocyte
Category Class of which the cell type is a subclass.: myeloid cellCL:0000763
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: KIT, CPA3
Canonical Marker Genes: KIT, CPA3
Rationale: KIT (CD117) is a receptor tyrosine kinase broadly used to identify mast cells across tissues. CPA3 (carboxypeptidase A3) is a mast cell-specific serine protease stored in secretory granules. Together these markers reliably identify mast cells and distinguish them from other immune cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Level 2 cell type labels (represents broad clusters most studies tend to identify).
Annotation Method: manual