Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.
—
Rationale
MS4A1 (CD20) is a surface marker broadly expressed on mature B cells. CD79A is a component of the B cell receptor signaling complex and confirms B cell lineage identity. IGKC (immunoglobulin kappa constant) reflects active immunoglobulin expression characteristic of B cells. Together these markers reliably identify B cells and distinguish them from other lymphoid populations.
