Human Adipose Tissue Atlas v1.0 — Cervical Subcutaneous WAT

Adipocytes

Ontology Term: adipocyteCL:0000136
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: white adipose cell, white fat cell, adipose cell, fat cell
Category Class of which the cell type is a subclass.: connective tissue cellCL:0002320
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ADIPOQ, PLIN1
Canonical Marker Genes: ADIPOQ, PLIN1
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: ADIPOQ and PLIN1 are established markers of mature adipocytes. ADIPOQ (adiponectin) is a hormone abundantly and selectively expressed by differentiated adipocytes and reflects their metabolic and endocrine function. PLIN1 (perilipin-1) is a lipid droplet–associated protein essential for lipid storage and lipolysis regulation, marking cells with mature adipocyte morphology. ADIPOQ and PLIN1 reliably identify differentiated adipocytes and distinguish them from stromal and progenitor cell populations.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Level 2 cell type labels (represents broad clusters most studies tend to identify).
Annotation Method: manual