snRNA-seq of the human retinal pigment epithelium and the choroid

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Cell Metadata

RPE_Fetal

Ontology Term: retinal pigment epithelial cellCL:0002586
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: retinal cellCL:0009004
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PAX6, KCND2, NRG1
Canonical Marker Genes: PAX6
Rationale: This RPE Fetal sub-class is annotated by its expression in cells from Fetal, and expression of RPE maturation marker PAX6, and specific expression of KCND2

Set of Labels Description: This cell annotation dataset focuses on the human retinal pigment epithelium (RPE) and choroid, which are essential for the survival and proper function of the neural retina in the human eye. Using single-nucleus RNA sequencing (snRNA-seq), we analyzed over 740K nuclei from 54 donors. Additionally, we incorporated snRNA-seq data from 136,555 nuclei from developmental RPE/choroid tissues spanning post-conception weeks (PCW) 10-23. This comprehensive dataset enabled the identification of 17 major cell classes and 36 sub-classes. As part of the Human Cell Atlas initiative, this resource lays a robust foundation for advancing research into the biology of the RPE and choroid and the diseases associated with these tissues.
Annotation Method: manual

Ontology Term: retinal pigment epithelial cellCL:0002586
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: retinal cellCL:0009004
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PAX6, KCND2, NRG1
Canonical Marker Genes: PAX6
Rationale: This RPE Fetal sub-class is annotated by its expression in cells from Fetal, and expression of RPE maturation marker PAX6, and specific expression of KCND2

Set of Labels Description: This cell annotation dataset focuses on the human retinal pigment epithelium (RPE) and choroid, which are essential for the survival and proper function of the neural retina in the human eye. Using single-nucleus RNA sequencing (snRNA-seq), we analyzed over 740K nuclei from 54 donors. Additionally, we incorporated snRNA-seq data from 136,555 nuclei from developmental RPE/choroid tissues spanning post-conception weeks (PCW) 10-23. This comprehensive dataset enabled the identification of 17 major cell classes and 36 sub-classes. As part of the Human Cell Atlas initiative, this resource lays a robust foundation for advancing research into the biology of the RPE and choroid and the diseases associated with these tissues.
Annotation Method: manual