We present the Human Liver Cell Atlas (HLiCA), integrating non-disease liver data from eight datasets across six research centers, covering 520,000+ cells from 110 donors. Developed in collaboration with the Human Cell Atlas Liver Bionetwork, the atlas incorporates expert-reviewed cell annotations, extensive feedback, and focused jamborees for refining myeloid and hepatocyte classifications.
A total of 47 liver cell types were identified from over 520,000 cells in the current atlas.
Epithelial cells lining the bile ducts, involved in bile production and modification.
Structural and supportive cells including fibroblasts and stellate cells, contributing to liver architecture.
Innate immune cells including macrophages and dendritic cells, key in tissue homeostasis and immune surveillance.
Adaptive immune cells such as T cells, B cells, and NK cells, involved in immune regulation and response.
Cells lining the liver vasculature, including liver sinusoidal endothelial cells, regulating filtration and cell trafficking.
The main parenchymal liver cells responsible for metabolism, detoxification, and protein synthesis.
