Human PBMC atlas - TCD4 effector and nonnaive cells

T CD4 naive/CM Treg

Full Name: naive, central memory regulatory T cell
Closest Ontology Term: regulatory T cellCL:0000815
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: regulatory T cellCL:0000815
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: Regulatory T cells have been reported previously, but we differentiate subtypes, here defined by canonical naive and central memory genes
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CCR7, LEF1
Canonical Marker Genes: CD4, FOXP3
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: Regulatory T cells have been reported previously, but we differentiate subtypes, here defined by canonical naive and central memory genes

Set of Labels Description: Clustering was Leiden based before manual annotation and consensus agreement by multiple authors.
Annotation Method: manual