Human PBMC atlas - TCD4 effector and nonnaive cells

Main

Summary

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Cell Metadata

Summary

Our TCD4 effector and nonnaive cells dataset includes 752,083 cells, using canonical markers to distinguish 28 unique subsets.

Metadata

Dataset Type: Integrated. The file includes an integrated collection of datasets.
Total Cells: 749,849
organism: Homo sapiens
tissue: blood
assay: 10x 5' v1 (224,333 cells)10x 5' v2 (219,868 cells)10x 3' v2 (207,082 cells)10x 3' v3 (98,566 cells)
disease: normal (390,307 cells)COVID-19 (272,526 cells)systemic lupus erythematosus (49,707 cells)infectious disease with sepsis (11,936 cells)respiratory system disorder (9,127 cells)post-COVID-19 disorder (8,886 cells)bacterial pneumonia (3,415 cells)influenza (1,981 cells)infectious disease (1,769 cells)viral pneumonia (195 cells)

Cell Labels

Level_4

Description

Clustering was Leiden based before manual annotation and consensus agreement by multiple authors.

Annotation Method

manual

T CD4 EM Th1

76,987

T CD4 CTL ADGRG1lo

53,013

T CD4 EM Th1 activ NR4A2

50,358

T CD4 CM LMNA

45,576

T CD4 CM quiesc

44,171

T CD4 CTL ADGRG1hi HLA

43,889

T CD4 EM Treg HLA DUSP4

36,095

34,686

34,310

33,410

33,169

T CD4 CM Tfh activ FOS_JUN HLA

32,411

Level_1

Description

Similar clusters with shared features from level 2 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

TCD4

749,849

Level_2

Description

Similar clusters with shared features from level 3 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

T CD4 Memory/Effector

716,439

T CD4 Naive

33,410

Level_3

Description

Similar clusters with shared features from level 4 were manually merged to one level higher in the hierarchy to determine clustering.

Annotation Method

manual

356,038

235,852

124,549

33,410

Human PBMC atlas - TCD4 effector and nonnaive cells

Main

Cell Metadata

Summary

Our TCD4 effector and nonnaive cells dataset includes 752,083 cells, using canonical markers to distinguish 28 unique subsets.

Metadata

Dataset Type: Integrated. The file includes an integrated collection of datasets.
Total Cells: 749,849
organism: Homo sapiens
tissue: blood
assay: 10x 5' v1 (224,333 cells)10x 5' v2 (219,868 cells)10x 3' v2 (207,082 cells)10x 3' v3 (98,566 cells)
disease: normal (390,307 cells)COVID-19 (272,526 cells)systemic lupus erythematosus (49,707 cells)infectious disease with sepsis (11,936 cells)respiratory system disorder (9,127 cells)post-COVID-19 disorder (8,886 cells)bacterial pneumonia (3,415 cells)influenza (1,981 cells)infectious disease (1,769 cells)viral pneumonia (195 cells)