Human PBMC atlas - TCD4 effector and nonnaive cells

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Cell Metadata

T CD4 CTL ADGRG1hi HLA

Full Name: HLA, ADGRG1high CD4-positive, alpha-beta cytotoxic T cell
Closest Ontology Term: CD4-positive, alpha-beta cytotoxic T cellCL:0000934
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: CD4-positive, alpha-beta cytotoxic T cellCL:0000934
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: We differentiate canonical cytotoxic cells by ADGRG1 expressions, here ADGRG1 high expression in addition to HLA genes
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ADGRG1, HLA-DRB1
Canonical Marker Genes: CD4, GZMH, PRF1, GNLY
Rationale: We differentiate canonical cytotoxic cells by ADGRG1 expressions, here ADGRG1 high expression in addition to HLA genes
Rationale DOI: https://doi.org/10.3389/fimmu.2025.1653970 https://doi.org/10.1038/s41467-022-31519-6

Set of Labels Description: Clustering was Leiden based before manual annotation and consensus agreement by multiple authors.
Annotation Method: manual

Full Name: HLA, ADGRG1high CD4-positive, alpha-beta cytotoxic T cell
Closest Ontology Term: CD4-positive, alpha-beta cytotoxic T cellCL:0000934
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: CD4-positive, alpha-beta cytotoxic T cellCL:0000934
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: We differentiate canonical cytotoxic cells by ADGRG1 expressions, here ADGRG1 high expression in addition to HLA genes
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ADGRG1, HLA-DRB1
Canonical Marker Genes: CD4, GZMH, PRF1, GNLY
Rationale: We differentiate canonical cytotoxic cells by ADGRG1 expressions, here ADGRG1 high expression in addition to HLA genes
Rationale DOI: https://doi.org/10.3389/fimmu.2025.1653970 https://doi.org/10.1038/s41467-022-31519-6

Set of Labels Description: Clustering was Leiden based before manual annotation and consensus agreement by multiple authors.
Annotation Method: manual