Human Gut Cell Atlas (HGCA) v1 - Epithelial Lineage

Colonocyte Progenitors

Full Name: colonocyte progenitor cell
Closest Ontology Term: early colonocyteCL:4047018
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: absorptive progenitor, colonocyte early progenitor
Category Class of which the cell type is a subclass.: colonocyteCL:1000347
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: No specific CL term for colonocyte progenitors - we separate these from early colonocytes to provide more resolution on epithelial subtypes
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: NOTCH1, EDN1
Canonical Marker Genes: NOTCH1, EDN1
Rationale: Absorptive colonic progenitors, NOTCH1 and EDN1 with some residual cycling, committed towards the colonocyte lineage but not yet showing surface maturation like AQP8. There isn't a colonocyte progenitor term so these map to early colonocyte.

Set of Labels Description: Cell annotations based on two rounds of subclustering with scVI integration, sample_id as batch key. Cell annotations were refined by expert feedback based on "prelim annotation" on CAP. Prelim annotation is renamed "hgca_celltype_v0" here and the feedback on the "prelim annotation" is available by selecting a previous version of the Integrated Human Gut Atlas on CAP.
Annotation Method: both
Algorithm Name: scIB
Algorithm Version: 1.2.1
Algorithm URL: https://github.com/theislab/scib