Disagreements with any aspect of the Cell Ontology.
GCA supports an intermediate between early and late absorptive colonocytes and enterocytes, based on coexpression of early and late markers and middling positioning on the continuum of epithelia
Marker Gene Evidence
Gene markers used by researcher to assign this cell annotation.
Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.
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Rationale
Enterocytes partway up the crypt, these display ANPEP and ALDOB alongside APOA1 and APOC3. They are placed clearly in the middle of the enterocyte maturation trajectory.
Inherited from hgca_celltype_v1
Set of Labels Description
Cell annotations based on two rounds of subclustering with scVI integration, sample_id as batch key. Cell annotations were refined by expert feedback based on "prelim annotation" on CAP. Prelim annotation is renamed "hgca_celltype_v0" here and the feedback on the "prelim annotation" is available by selecting a previous version of the Integrated Human Gut Atlas on CAP.
