Follicle Associated Resident Macrophages
Full Name
- follicle associated tissue resident macrophage
Closest Ontology Term
- tissue-resident macrophageCL:0000864
Synonyms
Terms that have the same, or nearly the same, meaning as the selected cell type.- PLA2G2D+ tissue resident macrophages; PLA2G2D macrophages
Category
Class of which the cell type is a subclass.- tissue-resident macrophageCL:0000864
Ontology Assessment
Disagreements with any aspect of the Cell Ontology.- This is a tissue resident macrophage within or next to a lymphoid follicle and participates in maintenance of the lymphoid niche. In human intestine and spleen, follicle-associated macrophage populations are characterized by lipid-regulatory programs including PLA2G2D and PTGDS, with MMP9 observed in corresponding human splenic populations.
Marker Gene Evidence
Gene markers used by researcher to assign this cell annotation.- PLA2G2D, PTGDS, MMP9
Rationale
- Tissue resident by complement, SELELNOP expression, but show high expression of PTGDS and PLA2G2D; these have been shown to be enriched in analyzed isolated gut lymphoid structures.
Inherited from hgca_celltype_v1
- Set of Labels Description
- Cell annotations based on two rounds of subclustering with scVI integration, sample_id as batch key. Cell annotations were refined by expert feedback based on "prelim annotation" on CAP. Prelim annotation is renamed "hgca_celltype_v0" here and the feedback on the "prelim annotation" is available by selecting a previous version of the Integrated Human Gut Atlas on CAP.
- Annotation Method
- both
- Algorithm Name
- scIB
- Algorithm Version
- 1.2.1
- Algorithm URL
- https://github.com/theislab/scib
