Human Gut Cell Atlas (HGCA) v1 - Myeloid Lineage

cDC1

Ontology Term: conventional dendritic cellCL:0000990
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: cDC1
Category Class of which the cell type is a subclass.: dendritic cellCL:0000451
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CLEC9A, C1orf54, XCR1, DNASE1L3, SHTN1
Canonical Marker Genes: CLEC9A, XCR1, BATF3
Rationale: Expresses CLEC9A, XCR1, DNASE1L3, and related cross presentation machinery, matching the canonical transcriptional program of type 1 conventional dendritic cells described in human mucosal and lymphoid tissues
Rationale DOI: https://doi.org/10.1126/science.aah4573 https://doi.org/10.1038/s41586-021-03852-1

Set of Labels Description: Cell annotations based on two rounds of subclustering with scVI integration, sample_id as batch key. Cell annotations were refined by expert feedback based on "prelim annotation" on CAP. Prelim annotation is renamed "hgca_celltype_v0" here and the feedback on the "prelim annotation" is available by selecting a previous version of the Integrated Human Gut Atlas on CAP.
Annotation Method: both
Algorithm Name: scIB
Algorithm Version: 1.2.1
Algorithm URL: https://github.com/theislab/scib