snRNA-seq of human retinal pigment epithelium and the choroid - v1

Summary

This atlas is an integrated collection of over 700K cells, derived from single-nucleus RNA-seq data of the human retinal pigment epithelium and the choroid across the lifespan—including pediatric, and adult donors. These cells have been categorized into 17 major classes and 36 sub-classes.

Metadata

Dataset Type: Integrated. The file includes an integrated collection of datasets.
Total Cells: 715,619
assay: 10x 3' v3 (707,692 cells)10x 5' v2 (7,927 cells)
disease: normal
organism: Homo sapiens
tissue: chorioretinal region

Cell Labels

author_cell_type

Description

This cell annotation dataset focuses on the human retinal pigment epithelium (RPE) and choroid, which are essential for the survival and proper function of the neural retina in the human eye. Using single-nucleus RNA sequencing (snRNA-seq), we analyzed over 700K nuclei from 54 donors. This comprehensive dataset enabled the identification of 17 major cell classes and 36 sub-classes. As part of the Human Cell Atlas initiative, this resource lays a robust foundation for advancing research into the biology of the RPE and choroid and the diseases associated with these tissues.

Annotation Method

manual