Human breast and milk cell atlas

Fibroblast (FB)

Ontology Term: fibroblast of breastCL:0002555
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: fibroblast
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: COL1A1, DCN, FN1, IGFBP6, MMP2
Canonical Marker Genes: DCN, LUM, COL1A1
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: This cell type was annotated based robust seperation as a single cluster and on the canonical expression of COL1A1, DCN, FN1.
Rationale DOI: https://www.biorxiv.org/content/10.1101/430611v4

Set of Labels Description: Cell annotations based on broad clustering using Louvain clustering and canonical gene expression. Sub clustering was interrogated and robustness of clusters were investigated within samples as well as between clusters.
Annotation Method: both
Algorithm Name: igraph::cluster_louvain
Algorithm Version: 1.3.5
Algorithm URL: https://igraph.org/r/html/1.3.5/cluster_louvain.html
Annotation Transfer Reference: https://www.biorxiv.org/content/10.1101/430611v4
Annotation Transfer Description: No automation, however many of the markers were taken from pre-print by Murrow et al 2020