Single-cell eQTL mapping identifies cell type specific genetic control of autoimmune disease

Summary

OneK1K cohort, which consists of single-cell RNA sequencing (scRNA-seq) data from 1.27 million peripheral blood mononuclear cells (PMBCs) collected from 982 donors.

Metadata

Dataset Type

Single. The file includes a single dataset whereby “dataset” means a single library or a set of technical replicates that can be combined without having to worry about the associated batch effect.

Total Cells

1,248,980

organism

Homo sapiens

tissue

blood

assay

10x 3' v2

disease

normal

Cell Labels

cell_type (29)

1,248,980 cells

central memory CD4-positive, alpha-beta T cell

289,000

naive thymus-derived CD4-positive, alpha-beta T cell

259,012

natural killer cell

164,933

effector memory CD8-positive, alpha-beta T cell

161,051

naive B cell

65,702

naive thymus-derived CD8-positive, alpha-beta T cell

52,538

CD14-positive monocyte

36,130

effector memory CD4-positive, alpha-beta T cell

31,261

memory B cell

30,234

transitional stage B cell

29,889

regulatory T cell

26,531

gamma-delta T cell

18,922

CD4-positive, alpha-beta cytotoxic T cell

17,993

central memory CD8-positive, alpha-beta T cell

16,409

CD14-low, CD16-positive monocyte

15,743

mucosal invariant T cell

8,835

CD16-negative, CD56-bright natural killer cell, human

7,006

conventional dendritic cell

4,570

plasmablast

3,754

plasmacytoid dendritic cell

1,897

double negative thymocyte

1,824

hematopoietic precursor cell

1,812

platelet

1,810

CD4-positive, alpha-beta T cell

773

innate lymphoid cell

444

CD8-positive, alpha-beta T cell

305

erythrocyte

290

dendritic cell

181

peripheral blood mononuclear cell

131