Single cell atlas of the human trabecular meshwork and ciliary body - snRNA-seq

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Cell Metadata

CB_NPCE_2

Ontology Term: non-pigmented ciliary epithelial cellCL:0002304
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: NPE cell
Category Class of which the cell type is a subclass.: neurecto-epithelial cellCL:0000710
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: GRID2, RELN, DCDC1, MYRIP, DCT
Canonical Marker Genes: LRP2, COL9A1, OPTC
Rationale: This non-pigmented ciliary epithelial sub-class is annotated by the marker LRP2, COL9A1 and OPTC, but distinct from CB_NPCE_1 claster with different express genes

Set of Labels Description: This cell annotation set focuses on the trabecular meshwork (TM) and ciliary body (CB), key tissues regulating aqueous humor dynamics and intraocular pressure in the human eye. Using single-nucleus RNA-seq, we analyzed over 1 million cells from 70 healthy donors, identifying 9 major cell classes and 18 sub-classes. As part of the Human Cell Atlas initiative, this dataset integrates transcriptomic and chromatin accessibility data and is publicly accessible via CELLxGENE and the UCSC Cell Browser, offering a valuable resource for understanding ocular physiology and disease mechanisms.
Annotation Method: manual

Ontology Term: non-pigmented ciliary epithelial cellCL:0002304
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: NPE cell
Category Class of which the cell type is a subclass.: neurecto-epithelial cellCL:0000710
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: GRID2, RELN, DCDC1, MYRIP, DCT
Canonical Marker Genes: LRP2, COL9A1, OPTC
Rationale: This non-pigmented ciliary epithelial sub-class is annotated by the marker LRP2, COL9A1 and OPTC, but distinct from CB_NPCE_1 claster with different express genes

Set of Labels Description: This cell annotation set focuses on the trabecular meshwork (TM) and ciliary body (CB), key tissues regulating aqueous humor dynamics and intraocular pressure in the human eye. Using single-nucleus RNA-seq, we analyzed over 1 million cells from 70 healthy donors, identifying 9 major cell classes and 18 sub-classes. As part of the Human Cell Atlas initiative, this dataset integrates transcriptomic and chromatin accessibility data and is publicly accessible via CELLxGENE and the UCSC Cell Browser, offering a valuable resource for understanding ocular physiology and disease mechanisms.
Annotation Method: manual