Single cell atlas of the human trabecular meshwork and ciliary body - snRNA-seq

Schwann-nmy

Ontology Term

non-myelinating Schwann cellCL:0002376

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

Schwann cell

Category

Class of which the cell type is a subclass.

Schwann cellCL:0002573

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

SCN7A, NRXN1

Canonical Marker Genes

SCN7A

Rationale

This non-myelinating Schwann cell sub-class is annotated by the marker SCN7A.

Inherited from author_cell_type

Set of Labels Description

This cell annotation set focuses on the trabecular meshwork (TM) and ciliary body (CB), key tissues regulating aqueous humor dynamics and intraocular pressure in the human eye. Using single-nucleus RNA-seq, we analyzed over 1 million cells from 70 healthy donors, identifying 9 major cell classes and 18 sub-classes. As part of the Human Cell Atlas initiative, this dataset integrates transcriptomic and chromatin accessibility data and is publicly accessible via CELLxGENE and the UCSC Cell Browser, offering a valuable resource for understanding ocular physiology and disease mechanisms.

Annotation Method

manual