Myeloid cells from human liver dataset

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Cell Metadata

mature LAMs

Ontology Term: lipid-associated macrophageCL:4033086
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: TREM2+ macrophages
Category Class of which the cell type is a subclass.: macrophageCL:0000235
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: TREM2, GPNMB, CD9, RNASE1, OTOA, SBDS, A2M, APOC1, LGMN, FCGBP
Canonical Marker Genes: TREM2, CD9, SPP1, GPNMB, EMP1, FABP5, FBP1, CAPG, ACP5, LGALS3, ANKRD28, PLA2G7, FAM20C
Rationale: Marker genes are top 10 DEGs for this population compared with all others in the UMAP (from Table S2 in publication). Canonical markers are the conserved human-mouse LAM signature genes we defined in the publication.

Set of Labels Description: Annotation of cell types in dataset based on prior knowledge
Annotation Method: manual

Ontology Term: lipid-associated macrophageCL:4033086
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: TREM2+ macrophages
Category Class of which the cell type is a subclass.: macrophageCL:0000235
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: TREM2, GPNMB, CD9, RNASE1, OTOA, SBDS, A2M, APOC1, LGMN, FCGBP
Canonical Marker Genes: TREM2, CD9, SPP1, GPNMB, EMP1, FABP5, FBP1, CAPG, ACP5, LGALS3, ANKRD28, PLA2G7, FAM20C
Rationale: Marker genes are top 10 DEGs for this population compared with all others in the UMAP (from Table S2 in publication). Canonical markers are the conserved human-mouse LAM signature genes we defined in the publication.

Set of Labels Description: Annotation of cell types in dataset based on prior knowledge
Annotation Method: manual