Dorsomedial shell
Explore other scientists feedback or go to the Molecular Data page and select a cell label to provide your feedback.
Dorsomedial shell
OK I disagree with the use of the word hybrid for 2 reasons. 1. They're not all DRD1/DRD2 positive 2. Hybrid implies that they're an offspring or fusion of two things, however I think this is incorrect. In my grad school work, I identified these cells as originating in the dLGE (like the MEIS2 cells which migrate into the OB, white matter, etc), but postnatally adopt a more MSN-like fate. I, and the original "eccentric" spiny neuron paper identify these cells as distinct from early development by being TSHZ1/FOXP2/OPRM1/CASZ1 high and FOXP1 low/negative (OTOF isn't a good marker for them), and it appears that that in adult primate this identity throughline is pretty clear. https://doi.org/10.1038/s41586-022-04510-w https://doi.org/10.1016/j.cell.2018.07.028 I think calling them eccentric is maybe not ideal, but would pay homage to the original discovery and what they've been known as. You could choose a different name, but I think "hybrid" as a descriptor for the subclass is specifically misleading due to its incompleteness and connotations in the evolutionary literature and so should be changed.