BoneMarrowMap: A Balanced Single-cell Reference Atlas of Human Hematopoiesis

Summary

We provide a large-scale reference atlas of human hematopoiesis with balanced representation of CD34+ stem and progenitor cells together with terminally differentiated populations. Our reference map of 263,159 hematopoietic cells provides us with deep portraits of lineage transitions in both early and late stages of human hematopoiesis, spanning 55 cellular states.

Metadata

Dataset Type

Integrated. The file includes an integrated collection of datasets.

Total Cells

263,159

organism

Homo sapiens

tissue

bone marrow

assay

10x 3' v2 (251,008 cells)10x 3' v3 (12,151 cells)

disease

normal

Cell Labels

AuthorCellType (55)

263,159 cells

CD4 Naive

24,063

CD14 Mono

23,957

HSC

12,641

CD4 Central Memory

12,152

Early GMP

11,432

Cycling Progenitor

9,366

CD8 Naive

8,502

CD8 Effector Memory 2

8,486

Pro-Erythroblast

7,390

CD4 Effector Memory

7,361

CFU-E

7,318

Mature B

6,730

LMPP

6,718

BFU-E

6,554

MPP-MkEry

5,771

NK

5,771

MPP-MyLy

5,591

Basophilic Erythroblast

5,253

Early ProMono

5,086

Polychromatic Erythroblast

5,061

CD16 Mono

4,996

Pro-B VDJ

4,909

MEP

4,856

GMP-Mono

4,557

pDC

4,269

Orthochromatic Erythroblast

3,734

cDC2

3,714

Pre-cDC

3,704

GMP-Neut

3,518

Large Pre-B

3,488

CD8 Effector Memory 1

3,360

Late ProMono

2,993

Plasma Cell

2,539

CD8 Central Memory

2,458

Pre-pDC

2,179

Megakaryocyte Precursor

2,053

GMP-Cycle

1,993

NK CD56high

1,935

EoBasoMast Precursor

1,930

Pre-pDC Cycling

1,880

Immature B

1,751

CD4 Regulatory

1,538

CD8 Tissue Resident Memory

1,478

CLP

1,274

MLP

1,242

Small Pre-B

1,213

Pro-B Cycling

1,118

Pre-ProB

787

T Proliferating

580

ASDC

552

MLP-II

506

cDC1

370

NK Proliferating

215

Stromal

213

Megakaryocyte

54