HCA Gut Cell Atlas v1 Epithelial Lineage

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Cell Metadata

Enterocytes Late

Full Name: Late enterocytes
Closest Ontology Term: intestinal absorptive cellCL:0000584
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: enterocyteCL:0000584
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: Since absorptive epithelial cells lay on a continuum, it's not clear if or how we should have subdivisions of epithelial subtypes. We argue it could be useful for high-res compositional analysis to have some type of subdivision.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: APOA1, APOC3, APOB, GUCA2A, CDHR5, DUOX2
Canonical Marker Genes: APOA1, APOB, CDHR5
Rationale: Enterocytes which are maturing closer to the lumen upregulate lipid packaging (APO) and DUOX2, an antimicrobial oxidase most active in the apical cells of the villi.

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: algorithmic

Full Name: Late enterocytes
Closest Ontology Term: intestinal absorptive cellCL:0000584
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: enterocyteCL:0000584
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: Since absorptive epithelial cells lay on a continuum, it's not clear if or how we should have subdivisions of epithelial subtypes. We argue it could be useful for high-res compositional analysis to have some type of subdivision.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: APOA1, APOC3, APOB, GUCA2A, CDHR5, DUOX2
Canonical Marker Genes: APOA1, APOB, CDHR5
Rationale: Enterocytes which are maturing closer to the lumen upregulate lipid packaging (APO) and DUOX2, an antimicrobial oxidase most active in the apical cells of the villi.

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: algorithmic