HCA Gut Cell Atlas v1 Myeloid Lineage

DC migDC

Full Name

migratory dendritic cell

Closest Ontology Term

dendritic cellCL:0000451

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

migratory DCs, migratory dendritic cells

Category

Class of which the cell type is a subclass.

dendritic cellCL:0000451

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

migratory DCs are a well described rare celltype relevant to mucosal biology that are increasingly being annotated in single cell atlases - they should have a cell ontology label!

Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

LAMP3, IDO1, CCR7, CD40, CCL5

Canonical Marker Genes

LAMP3, CCR7, IDO1

Rationale

LAMP3, CCR7, IDO1, CD40, CCL5, capture the antigen experienced, lymph node directed migratory DC state which has been repeatedly observed in barrier tissues

Rationale DOI

10.1084/jem.20222129

Inherited from Prelim annotation

Set of Labels Description

Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering

Annotation Method

both

Algorithm Name

scVI

Algorithm Version

1.3.2

Algorithm URL

https://github.com/scverse/scvi-tools