Fibroblasts annotated as Subserosal are enriched for DPT, C7 and POSTN and tend to form deeper fibroblast clusters with lower dataset diversity (for example Stroma_8_0 and 8_1). We note that some clusters labeled as Subserosal in the original annotations appear in many biopsy-derived datasets, so we question whether they are truly subserosal versus generally deeper S3 fibroblasts. Do we need a deeper S3 fibroblast annotation? We therefore sometimes use the Intestinal Subserosal Fibroblasts and sometimes S3 term for DPT+/C7+/POSTN+ deeper fibroblasts while acknowledging that the exact boundary between subserosal and submucosal S3 fibroblasts is still being refined.
Inherited from Prelim annotation
Set of Labels Description
Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
