HCA Gut Cell Atlas v1 Stromal Lineage

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Cell Metadata

Glia Intra-Ganglionic

Ontology Term: type I enteric glial cellCL:4047047
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: glial cellCL:0000125
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: APOE, FRZB, RLBP1, CRYM
Canonical Marker Genes: APOE, RLBP1, CRYM
Rationale: This label corresponds to glia located within enteric ganglia, matching the type I enteric glial cell definition and showing enrichment for APOE, FRZB, RLBP1, CRYM and other neuro-supportive genes. Clusters annotated as Glia Intra-Ganglionic are present across multiple datasets and sit transcriptionally between myenteric and submucosal plexus glia, consistent with the canonical intra-ganglionic location.

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: both
Algorithm Name: scVI
Algorithm Version: 1.3.2
Algorithm URL: https://github.com/scverse/scvi-tools

Ontology Term: type I enteric glial cellCL:4047047
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: glial cellCL:0000125
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: APOE, FRZB, RLBP1, CRYM
Canonical Marker Genes: APOE, RLBP1, CRYM
Rationale: This label corresponds to glia located within enteric ganglia, matching the type I enteric glial cell definition and showing enrichment for APOE, FRZB, RLBP1, CRYM and other neuro-supportive genes. Clusters annotated as Glia Intra-Ganglionic are present across multiple datasets and sit transcriptionally between myenteric and submucosal plexus glia, consistent with the canonical intra-ganglionic location.

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: both
Algorithm Name: scVI
Algorithm Version: 1.3.2
Algorithm URL: https://github.com/scverse/scvi-tools