HCA Gut Cell Atlas v1 Epithelial Lineage

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Cell Metadata

Colonocytes Laminin

Full Name: Laminin producing colonocytes
Closest Ontology Term: colonocyteCL:1000347
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: colonocyteCL:1000347
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: Since absorptive epithelial cells lay on a continuum, it's not clear if or how we should have subdivisions of epithelial subtypes. We argue it could be useful for high-res compositional analysis to have some type of subdivision.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: LAMA3, MUC17, LMC2, LMO7
Canonical Marker Genes: LAMA3, MUC17, LAMC2
Rationale: We found a common subcluster of hypothetically basement membrane laminin producing specialized colonocytes which we separate as an outgroup here based on multiple basement membrane scaffold proteins, LAMA and MUC17

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: algorithmic

Full Name: Laminin producing colonocytes
Closest Ontology Term: colonocyteCL:1000347
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: colonocyteCL:1000347
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: Since absorptive epithelial cells lay on a continuum, it's not clear if or how we should have subdivisions of epithelial subtypes. We argue it could be useful for high-res compositional analysis to have some type of subdivision.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: LAMA3, MUC17, LMC2, LMO7
Canonical Marker Genes: LAMA3, MUC17, LAMC2
Rationale: We found a common subcluster of hypothetically basement membrane laminin producing specialized colonocytes which we separate as an outgroup here based on multiple basement membrane scaffold proteins, LAMA and MUC17

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: algorithmic