BEST2, KLK3/15, MUC1/2+ --> Secretory goblet cells. See e.g. here: https://www.nature.com/articles/s41586-021-03852-1?utm_source=chatgpt.com
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BEST2, KLK3/15, MUC1/2+ --> Secretory goblet cells. See e.g. here: https://www.nature.com/articles/s41586-021-03852-1?utm_source=chatgpt.com
generally agree, but the cells very close to the secretory goblet cells that still belong to the "early enterocytes" cluster also seem to be quite high for goblet cell markers. MUC2hi, SPINK4, AGR2... Split cluster?
Clear! LGR5+ OLFM5, SMOC2...
Mixed cell profile. Some epithelial cells some B cells?
TNFAIP2+, CCL23+, SOX8+, GP2+ Clear M cells. See also here as reference. https://www.nature.com/articles/s41586-025-09829-8
I think these might be more circulating neutrophils? Definitely myeloid immune cells. CSF3R, FCGR3B, S100A12, SELL... Either way, these cells should be probably deleted from an epithelial cell object.
Agree to this label. Should be removed from this object as not an epithelial cell but contamination.