HCA Gut Cell Atlas v1 Epithelial Lineage

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Cell Metadata

Enterocytes

Ontology Term: enterocyteCL:0000584
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: epithelial cellCL:0000066
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CCL25, EPCAM, KRT*, ELF3
Canonical Marker Genes: EPCAM, KRT8, KRT18
Rationale: Enterocytes here are the absorptive epithelial cells of the small intestine. These express high levels of keratin and mitochondrial genes and are unique in each suborgan - duodenum and ileum. We should think about how to categorize duodenal vs. jejunal vs ileal enterocytes. EPCAM is the lineage defining marker here but does not appear in single cell data. Here, enterocytes are subdivided into early and late lifecycle subtypes, when neither of these can be determined, the broader label is used

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: algorithmic

Ontology Term: enterocyteCL:0000584
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: epithelial cellCL:0000066
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CCL25, EPCAM, KRT*, ELF3
Canonical Marker Genes: EPCAM, KRT8, KRT18
Rationale: Enterocytes here are the absorptive epithelial cells of the small intestine. These express high levels of keratin and mitochondrial genes and are unique in each suborgan - duodenum and ileum. We should think about how to categorize duodenal vs. jejunal vs ileal enterocytes. EPCAM is the lineage defining marker here but does not appear in single cell data. Here, enterocytes are subdivided into early and late lifecycle subtypes, when neither of these can be determined, the broader label is used

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: algorithmic