HCA Gut Cell Atlas v1 Epithelial Lineage

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Cell Metadata

Microfold Cells (M Cells)

Ontology Term: M cell of gutCL:0000682
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: epithelial cellCL:0000066
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: TGM2, NOS2, CCL20, REG3G, RANK, GP2, SPIB, SOX8, CLU, TNFAIP2, CCL23, MIA
Canonical Marker Genes: SPIB, GP2, TGM2
Rationale: Antigen sampling cells that transport lumen antigens to the immune compartment below them. These can be difficult to identify because canonical markers like SPIB are found in enterocytes as well. Some subclusters were high in NOS2 and TGM2 so we gave this label

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: algorithmic

Ontology Term: M cell of gutCL:0000682
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: epithelial cellCL:0000066
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: TGM2, NOS2, CCL20, REG3G, RANK, GP2, SPIB, SOX8, CLU, TNFAIP2, CCL23, MIA
Canonical Marker Genes: SPIB, GP2, TGM2
Rationale: Antigen sampling cells that transport lumen antigens to the immune compartment below them. These can be difficult to identify because canonical markers like SPIB are found in enterocytes as well. Some subclusters were high in NOS2 and TGM2 so we gave this label

Set of Labels Description: Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
Annotation Method: algorithmic