Glia Submucosal Plexus / Type I
Ontology Term
- type 1 submucosal plexus gliaCL:4047043
Synonyms
Terms that have the same, or nearly the same, meaning as the selected cell type.- unknown
Category
Class of which the cell type is a subclass.- type I enteric glial cellCL:4047047
Ontology Assessment
Disagreements with any aspect of the Cell Ontology.- —
Marker Gene Evidence
Gene markers used by researcher to assign this cell annotation.- ENTPD2, SFRP5
Rationale
- This label is used for type I glia associated with the submucosal plexus, distinguished by expression of ENTPD2, SFRP5 and a core glial program and by their co-clustering with other submucosal plexus markers in integrated data. They are present across several datasets but enriched in samples with preserved submucosa, consistent with a submucosal plexus localization. The glial subtypes performed poorly in reference mapping benchmarks, so a lesser resolution is likely best for the data currently. Annotation experts also point to less confidence in glial subtypes
Inherited from Prelim annotation
- Set of Labels Description
- Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering
- Annotation Method
- both
- Algorithm Name
- scVI
- Algorithm Version
- 1.3.2
- Algorithm URL
- https://github.com/scverse/scvi-tools
