Seems to be mostly T cells with CD2, CD3, CD69?
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Seems to be mostly T cells with CD2, CD3, CD69?
Clearly a lymphoid tissue FRC cluster. CD24+ CCL19/CCL21+ CLU+ As CXCL13/CXCL14/FDCSP are also on the list, this is likely a T cell zone / B cell zone mixed cluster
Definitely containing some enterocytes. CLDN1, CALB2, PDZK1IP1
I think this label is in line with the Elmentaite et al paper (https://www.nature.com/articles/s41586-021-03852-1). However, given that some of the main DEG are e.g. TNFSF11 and CXCL14, I think one could also label them MRC = marginal reticular cells. Especially TNSF11 is a hallmark of MRC from secondary lymphoid tissues such as Peyers patches and isolated lymphoid follicles. (https://www.nature.com/articles/s41590-021-00894-5); (10.1084/jem.20250471)
Surely containing plasma cells (MZB1, JCHAIN, CD79A), but also other lymphocytes (likely incl. T cells IL7R, CD69hi). As this is a stromal cell object, they cluster together. Delete this cluster from this object?