Human lymph nodes with partial T and B cell depletion

HLA-DRhi_ILC3

Ontology Term: group 3 innate lymphoid cell, humanCL:0001078
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: group 3 innate lymphoid cellCL:0001071
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: HLA-DRA, KIT, RORC, IL23R
Canonical Marker Genes: KIT, IL7R, CCR6, IL23R, AHR, RORC,
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: Top differential gene expression mapped most with NKp44- ILC3 in Azimuth tonsil dataset, high expression of HLA-DR and subpopulation of IL3 with high HLA-DR has been described (see DOI)
Rationale DOI: https://doi.org/10.1038/ni.3368

Set of Labels Description: Cell annotations were based on the finest possible label that could describe the 16 clusters found following integration and clustering.
Annotation Method: manual