Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults

Type I myonuclei, myofiber

Ontology Term

type I muscle cellCL:0002211

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

extrafusal muscle fiber

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

NEGR1, NOVA1, EBF1, LAMA2, GSN, COL6A3, CFD, APOD, CBLB, LAMC1

Canonical Marker Genes

ATP2A2, NEB, TNNT1, TPM3, SOX6, GBE1

Rationale

Cells in this cluster express high levels of ATP2A2, TNNT1, and TPM3, as well as TRDN, and MYBPC1

Inherited from author_cell_type

Set of Labels Description

Cell annotations were generated with scType using marker genes curated from related publications, and then manually reviewed and adjusted based on the top highly variable genes in each Leiden cluster.

Annotation Method

both

Algorithm Name

scType

Algorithm Version

v1

Algorithm URL

https://github.com/IanevskiAleksandr/sc-type