Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults

Type I myonuclei, myofiber

Ontology Term: type I muscle cellCL:0002211
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: extrafusal muscle fiber
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: NEGR1, NOVA1, EBF1, LAMA2, GSN, COL6A3, CFD, APOD, CBLB, LAMC1
Canonical Marker Genes: ATP2A2, NEB, TNNT1, TPM3, SOX6, GBE1
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: Cells in this cluster express high levels of ATP2A2, TNNT1, and TPM3, as well as TRDN, and MYBPC1

Set of Labels Description: Cell annotations were generated with scType using marker genes curated from related publications, and then manually reviewed and adjusted based on the top highly variable genes in each Leiden cluster.
Annotation Method: both
Algorithm Name: scType
Algorithm Version: v1
Algorithm URL: https://github.com/IanevskiAleksandr/sc-type