HCA Gut Cell Atlas v1 Myeloid Lineage

Granulocytes

Ontology Term

granulocyteCL:0000094

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

polymorphonuclear leukocytes, PMN, PML, PMNL

Category

Class of which the cell type is a subclass.

myeloid cellCL:0000763

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

—

Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

CLC, IL4, CPA3, FCGR2B

Canonical Marker Genes

CLC, FCGR3B, S100A12

Rationale

Expresses granulocytic effectors including CLC, IL4 inducible modules, CPA3, and Fcγ receptor associated genes, hint at polymorphonuclear granulocytes distinct from mast cells. Obviously a big ? given difficulty in picking these up with typical droplet-based protocols

Rationale DOI

10.1038/s41586-021-03852-1

Inherited from Prelim annotation

Set of Labels Description

Cell annotations (Prelim annotation) are based on the finest possible label that could be used to describe each of the ~500 clusters found during integration and subclustering

Annotation Method

both

Algorithm Name

scVI

Algorithm Version

1.3.2

Algorithm URL

https://github.com/scverse/scvi-tools