Integrated Human Breast Cell Atlas v1.0 - all cells

Main

Cell Metadata

Vascular endothelial

Ontology Term: endothelial cellCL:0000115
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: blood vascular endothelial cell, endothelial cell of blood vessel
Category Class of which the cell type is a subclass.: endothelial cellCL:0000115
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: The label 'Vascular endothelial' maps to CL:0000115 (endothelial cell) as the parent term encompassing venous, arterial, capillary, and tip cell subtypes present in the data. CL:0002138 (endothelial cell of lymphatic vessel) is used to distinguish lymphatic endothelial cells in this atlas.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SELE, ACKR1, IGFBP3, CXCL12, HEY1, KDR, ADGRF5, SPP1
Canonical Marker Genes: PECAM1, CDH5, VWF, CLDN5, EMCN
Rationale: Vascular endothelial cells were identified and annotated based on canonical marker expression including PECAM1, CDH5, VWF, and CLDN5. CL:0000115 (endothelial cell) is used as the parent term covering venous, arterial, capillary, and tip cell subtypes present in the data. Blood vascular endothelial identity is distinguished from lymphatic endothelial cells (LYVE1+/PROX1+).
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual

Ontology Term: endothelial cellCL:0000115
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: blood vascular endothelial cell, endothelial cell of blood vessel
Category Class of which the cell type is a subclass.: endothelial cellCL:0000115
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: The label 'Vascular endothelial' maps to CL:0000115 (endothelial cell) as the parent term encompassing venous, arterial, capillary, and tip cell subtypes present in the data. CL:0002138 (endothelial cell of lymphatic vessel) is used to distinguish lymphatic endothelial cells in this atlas.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SELE, ACKR1, IGFBP3, CXCL12, HEY1, KDR, ADGRF5, SPP1
Canonical Marker Genes: PECAM1, CDH5, VWF, CLDN5, EMCN
Rationale: Vascular endothelial cells were identified and annotated based on canonical marker expression including PECAM1, CDH5, VWF, and CLDN5. CL:0000115 (endothelial cell) is used as the parent term covering venous, arterial, capillary, and tip cell subtypes present in the data. Blood vascular endothelial identity is distinguished from lymphatic endothelial cells (LYVE1+/PROX1+).
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual