Integrated Human Breast Cell Atlas v1.0 - all cells

Luminal hormone sensing

Ontology Term

luminal hormone-sensing cell of mammary glandCL:4033058

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

LHS cell, luminal HR cell, hormone-responsive luminal cell, ER+ luminal cell, LumHR cell

Category

Class of which the cell type is a subclass.

mammary gland epithelial cellCL:0002327

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

SCGB2A2, PIP, SCGB1D2, MUCL1, KRT8, SYTL2, TFF3

Canonical Marker Genes

ESR1, PGR, AR, FOXA1, GATA3, TFF1

Rationale

Luminal hormone sensing (LHS) cells were identified and annotated based on ESR1+/PGR+/FOXA1+/GATA3+ expression. These cells are the ER+ luminal compartment responsible for hormone signal reception in the breast epithelium. See Reed et al. 2024 (Nature Genetics) for characterization. Note: formerly labeled 'LumHR' — standardized to LHS in this atlas version.

Rationale DOI

10.1038/s41588-024-01688-910.1038/s41586-023-06252-9

Inherited from level1_annotation

Set of Labels Description

Cell annotations based on resolution broad clustering using the Leiden algorithm.

Annotation Method

manual