Integrated Human Breast Cell Atlas v1.0 - all cells

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Cell Metadata

Basal-myoepithelial

Ontology Term: basal-myoepithelial cell of mammary glandCL:0002324
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: basal cell, myoepithelial cell, basal epithelial cell
Category Class of which the cell type is a subclass.: epithelial cellCL:0000066
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: TAGLN, KRT14, ACTA2, TPM2, KRT17, MT2A
Canonical Marker Genes: KRT5, KRT14, TP63, ACTA2, MYLK, OXTR
Rationale: Basal-myoepithelial cells were identified and annotated based on canonical marker expression including KRT5, KRT14, TP63, and ACTA2. These cells represent the contractile, TP63+/KRT5+/KRT14+ basal layer that surrounds luminal epithelial cells in breast ducts and lobules.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual

Ontology Term: basal-myoepithelial cell of mammary glandCL:0002324
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: basal cell, myoepithelial cell, basal epithelial cell
Category Class of which the cell type is a subclass.: epithelial cellCL:0000066
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: TAGLN, KRT14, ACTA2, TPM2, KRT17, MT2A
Canonical Marker Genes: KRT5, KRT14, TP63, ACTA2, MYLK, OXTR
Rationale: Basal-myoepithelial cells were identified and annotated based on canonical marker expression including KRT5, KRT14, TP63, and ACTA2. These cells represent the contractile, TP63+/KRT5+/KRT14+ basal layer that surrounds luminal epithelial cells in breast ducts and lobules.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual