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Integrated Human Breast Cell Atlas v1.0 - all cells | CAP
v1
Towards an anatomically resolved transcriptomic atlas of the human breast
Integrated Human Breast Cell Atlas v1.0 - all cells
Integrated Human Breast Cell Atlas v1.0 - all cells
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Summary
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Cell Metadata
level1_annotation
Luminal adaptive secretory precursor
Ontology Term
luminal adaptive secretory precursor cell of mammary gland
CL:4033057
Synonyms
Terms that have the same, or nearly the same, meaning as the selected cell type.
LASP cell, luminal progenitor, adaptive luminal cell
Category
Class of which the cell type is a subclass.
mammary gland epithelial cell
CL:0002327
Ontology Assessment
Disagreements with any aspect of the Cell Ontology.
—
Marker Gene Evidence
Gene markers used by researcher to assign this cell annotation.
SCGB3A1
,
MMP7
,
TM4SF1
,
PTN
,
WFDC2
,
HMGB2
,
TOP2A
Canonical Marker Genes
KRT18
,
KRT8
,
SLPI
,
ANKRD36C
,
KRT7
,
ALDH1A3
Rationale
Luminal adaptive secretory precursor (LASP) cells were identified and annotated based on KRT18+/KRT8+/SLPI+/ALDH1A3+ expression. These cells represent a progenitor-like luminal population. See Reed et al. 2024 (Nature Genetics) for characterization.
Rationale DOI
10.1038/s41588-024-01688-9
10.1038/s41586-023-06252-9
Inherited from level1_annotation
Set of Labels Description
Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method
manual
Molecular Data
