Integrated Human Breast Cell Atlas v1.0 - all cells

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Cell Metadata

Fibroblast

Ontology Term: fibroblast of mammary glandCL:0002555
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: breast fibroblast, stromal fibroblast
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: COL3A1, COL1A1, POSTN, MMP3, SFRP4, CFD, GPX3
Canonical Marker Genes: COL1A1, COL1A2, DCN, LUM, PDGFRA, VIM
Rationale: Fibroblasts were identified and annotated based on canonical marker expression including COL1A1, COL1A2, DCN, LUM, and PDGFRA. These COL1A1+/COL1A2+/DCN+ cells are the predominant stromal cell type in the breast, contributing to extracellular matrix deposition and tissue architecture.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual

Ontology Term: fibroblast of mammary glandCL:0002555
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: breast fibroblast, stromal fibroblast
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: COL3A1, COL1A1, POSTN, MMP3, SFRP4, CFD, GPX3
Canonical Marker Genes: COL1A1, COL1A2, DCN, LUM, PDGFRA, VIM
Rationale: Fibroblasts were identified and annotated based on canonical marker expression including COL1A1, COL1A2, DCN, LUM, and PDGFRA. These COL1A1+/COL1A2+/DCN+ cells are the predominant stromal cell type in the breast, contributing to extracellular matrix deposition and tissue architecture.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual