Integrated Human Breast Cell Atlas v1.0 - all cells

Fibroblast

Ontology Term

fibroblast of mammary glandCL:0002555

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

breast fibroblast, stromal fibroblast

Category

Class of which the cell type is a subclass.

fibroblastCL:0000057

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

COL3A1, COL1A1, POSTN, MMP3, SFRP4, CFD, GPX3

Canonical Marker Genes

COL1A1, COL1A2, DCN, LUM, PDGFRA, VIM

Rationale

Fibroblasts were identified and annotated based on canonical marker expression including COL1A1, COL1A2, DCN, LUM, and PDGFRA. These COL1A1+/COL1A2+/DCN+ cells are the predominant stromal cell type in the breast, contributing to extracellular matrix deposition and tissue architecture.

Rationale DOI

10.1038/s41588-024-01688-910.1038/s41586-023-06252-9

Inherited from level1_annotation

Set of Labels Description

Cell annotations based on resolution broad clustering using the Leiden algorithm.

Annotation Method

manual