Integrated Human Breast Cell Atlas v1.0 - all cells

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Cell Metadata

B-lymphocyte

Ontology Term: B cellCL:0000236
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: B cell, B-cell
Category Class of which the cell type is a subclass.: lymphocyteCL:0000542
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: The label 'B-lymphocyte' maps to CL:0000236 (B cell), the parent term encompassing naive, memory, and class-switched B cell subtypes. Plasma cells (CL:0000786) are a distinct differentiated state but are grouped under B-lymphocyte at this annotation level.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD79B, IGHM, TCL1A, IGHG1, IGHA1, IGHA2, JCHAIN
Canonical Marker Genes: MS4A1, CD79A, CD79B, BANK1, IGHM, CD19
Rationale: B lymphocytes were identified and annotated based on canonical marker expression including MS4A1, CD79A, IGHM, BANK1, and CD19. This label encompasses naive B cells, memory B cells, and class-switched B cells.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual

Ontology Term: B cellCL:0000236
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: B cell, B-cell
Category Class of which the cell type is a subclass.: lymphocyteCL:0000542
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: The label 'B-lymphocyte' maps to CL:0000236 (B cell), the parent term encompassing naive, memory, and class-switched B cell subtypes. Plasma cells (CL:0000786) are a distinct differentiated state but are grouped under B-lymphocyte at this annotation level.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD79B, IGHM, TCL1A, IGHG1, IGHA1, IGHA2, JCHAIN
Canonical Marker Genes: MS4A1, CD79A, CD79B, BANK1, IGHM, CD19
Rationale: B lymphocytes were identified and annotated based on canonical marker expression including MS4A1, CD79A, IGHM, BANK1, and CD19. This label encompasses naive B cells, memory B cells, and class-switched B cells.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual