Integrated Human Breast Cell Atlas v1.0 - all cells

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Cell Metadata

Lymphatic endothelial

Ontology Term: endothelial cell of lymphatic vesselCL:0002138
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: lymphatic endothelial cell, LEC
Category Class of which the cell type is a subclass.: endothelial cellCL:0000115
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: LYVE1, FABP4, CCL21, FABP5, PRSS23, NTS, CXCL8
Canonical Marker Genes: LYVE1, PROX1, PDPN, FLT4, RELN
Rationale: Lymphatic endothelial cells were identified and annotated based on canonical marker expression including LYVE1, PROX1, PDPN, and FLT4. These cells line the lymphatic vasculature of the breast and are distinguished from vascular endothelial cells by FLT4 expression and absence of PECAM1 at the level found in blood vessels.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual

Ontology Term: endothelial cell of lymphatic vesselCL:0002138
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: lymphatic endothelial cell, LEC
Category Class of which the cell type is a subclass.: endothelial cellCL:0000115
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: LYVE1, FABP4, CCL21, FABP5, PRSS23, NTS, CXCL8
Canonical Marker Genes: LYVE1, PROX1, PDPN, FLT4, RELN
Rationale: Lymphatic endothelial cells were identified and annotated based on canonical marker expression including LYVE1, PROX1, PDPN, and FLT4. These cells line the lymphatic vasculature of the breast and are distinguished from vascular endothelial cells by FLT4 expression and absence of PECAM1 at the level found in blood vessels.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual