Integrated Human Breast Cell Atlas v1.0 - all cells

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Cell Metadata

Lactocyte

Ontology Term: mammary gland epithelial cellCL:0002327
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: milk-secreting epithelial cell, lactating mammary epithelial cell
Category Class of which the cell type is a subclass.: mammary gland epithelial cellCL:0002327
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: The label 'Lactocyte' denotes milk-secreting mammary epithelial cells from lactating donors. CL:0002327 (mammary gland epithelial cell) is the closest available term; a more specific CL term for lactating mammary epithelial cells would better represent this population.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: LALBA, CSN1S1, CSN2, CSN3, LYZ, SPP1
Canonical Marker Genes: LALBA, CSN2, CSN3, LTF, GLYCAM1
Rationale: Lactocytes are milk-secreting mammary epithelial cells identified primarily from the Twigger et al. 2022 lactating donor dataset and annotated by Austin Reed based on high expression of milk protein genes including LALBA, CSN2, CSN3, and LTF. CL:0002327 is used as the closest available ontology term for this lactation-state-specific cell population.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9 10.1038/s41556-022-00856-5

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual

Ontology Term: mammary gland epithelial cellCL:0002327
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: milk-secreting epithelial cell, lactating mammary epithelial cell
Category Class of which the cell type is a subclass.: mammary gland epithelial cellCL:0002327
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: The label 'Lactocyte' denotes milk-secreting mammary epithelial cells from lactating donors. CL:0002327 (mammary gland epithelial cell) is the closest available term; a more specific CL term for lactating mammary epithelial cells would better represent this population.
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: LALBA, CSN1S1, CSN2, CSN3, LYZ, SPP1
Canonical Marker Genes: LALBA, CSN2, CSN3, LTF, GLYCAM1
Rationale: Lactocytes are milk-secreting mammary epithelial cells identified primarily from the Twigger et al. 2022 lactating donor dataset and annotated by Austin Reed based on high expression of milk protein genes including LALBA, CSN2, CSN3, and LTF. CL:0002327 is used as the closest available ontology term for this lactation-state-specific cell population.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9 10.1038/s41556-022-00856-5

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual