Human intercostal skeletal muscle aging atlas (scRNA-seq and snRNA-seq, young vs aged)

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Cell Metadata

SMC

Ontology Term: vascular associated smooth muscle cellCL:0000359
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: vascular smooth muscle cell, vSMC, SMC
Category Class of which the cell type is a subclass.: mural cellCL:0008034
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MYH11, PLN, SORBS2, LBH, CNN1, PERGL, RAMP1, CCL2
Canonical Marker Genes: ACTA2, MYH11, TAGLN
Rationale: This cell was annotated manually using canonical markers in the field (MYH11, ACTA2, TAGLN) with several subsets: RAMP1+, CCL2+ and pericyte intermediate. We noticed MYH11, RERGL, ACTG2 running differential expression. Vascular smooth muscle cell.
Rationale DOI: 10.1038/s41591-024-03376-x

Set of Labels Description: Displayed cell annotations represent 43 coarse cell type clusters derived using combined manual and automatic annotation using CellTypist.
Annotation Method: both
Algorithm Name: CellTypist
Algorithm Version: v1.7
Algorithm URL: https://github.com/Teichlab/celltypist

Ontology Term: vascular associated smooth muscle cellCL:0000359
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: vascular smooth muscle cell, vSMC, SMC
Category Class of which the cell type is a subclass.: mural cellCL:0008034
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MYH11, PLN, SORBS2, LBH, CNN1, PERGL, RAMP1, CCL2
Canonical Marker Genes: ACTA2, MYH11, TAGLN
Rationale: This cell was annotated manually using canonical markers in the field (MYH11, ACTA2, TAGLN) with several subsets: RAMP1+, CCL2+ and pericyte intermediate. We noticed MYH11, RERGL, ACTG2 running differential expression. Vascular smooth muscle cell.
Rationale DOI: 10.1038/s41591-024-03376-x

Set of Labels Description: Displayed cell annotations represent 43 coarse cell type clusters derived using combined manual and automatic annotation using CellTypist.
Annotation Method: both
Algorithm Name: CellTypist
Algorithm Version: v1.7
Algorithm URL: https://github.com/Teichlab/celltypist