Human intercostal skeletal muscle aging atlas (scRNA-seq and snRNA-seq, young vs aged)

FB

Ontology Term

skeletal muscle fibroblastCL:0011027

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

muscle fibroblast, stromal fibroblast, FB

Category

Class of which the cell type is a subclass.

fibroblastCL:0000057

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

—

Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

PDGFRA, DCN, FBN1, PRG4, PCOLCE2, CD70, COL4A1, COL15A1, ALDH1A2

Canonical Marker Genes

COL1A1, DCN, PDGFRA

Rationale

This cell was annotated manually using canonical markers in the field for fibroblasts (PDGFRA and DCN) and specific subsets including adventitial: FBN1, PRG4, PCOLCE2, CD70 and parenchymal fibroblasts:COL4A1, COL15A1, ALDH1A2. We noticed DCN, CFD, APOD running differential expression.

Rationale DOI

10.1038/s41586-021-03549-5

Inherited from author_cell_type

Set of Labels Description

Displayed cell annotations represent 43 coarse cell type clusters derived using combined manual and automatic annotation using CellTypist.

Annotation Method

both

Algorithm Name

CellTypist

Algorithm Version

v1.7

Algorithm URL

https://github.com/Teichlab/celltypist