Human intercostal skeletal muscle aging atlas (scRNA-seq and snRNA-seq, young vs aged)

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Cell Metadata

CD16+NK

Ontology Term: CD16-positive, CD56-dim natural killer cell, humanCL:0000939
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD56dim NK cell, cytotoxic NK
Category Class of which the cell type is a subclass.: natural killer cellCL:0000623
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FCGR3A, GZMB, FGFBP2, GNLY, PRF1, NKG7
Canonical Marker Genes: FCGR3A, GZMB, PRF1
Rationale: This cell was annotated with CellTypist using the Immune_All_Low model trained on the cross-tissue immune cell atlas (DOI: 10.1126/science.abl5197). Canonical markers in the field include FCGR3A, GZMB, FGFBP2, GNLY, PRF1, NKG7; we noticed GNLY, NKG7, KLRF1 running differential expression. Cytotoxic NK (CD56-dim).
Rationale DOI: 10.1126/science.abl5197

Set of Labels Description: Displayed cell annotations represent 43 coarse cell type clusters derived using combined manual and automatic annotation using CellTypist.
Annotation Method: both
Algorithm Name: CellTypist
Algorithm Version: v1.7
Algorithm URL: https://github.com/Teichlab/celltypist

Ontology Term: CD16-positive, CD56-dim natural killer cell, humanCL:0000939
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: CD56dim NK cell, cytotoxic NK
Category Class of which the cell type is a subclass.: natural killer cellCL:0000623
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: FCGR3A, GZMB, FGFBP2, GNLY, PRF1, NKG7
Canonical Marker Genes: FCGR3A, GZMB, PRF1
Rationale: This cell was annotated with CellTypist using the Immune_All_Low model trained on the cross-tissue immune cell atlas (DOI: 10.1126/science.abl5197). Canonical markers in the field include FCGR3A, GZMB, FGFBP2, GNLY, PRF1, NKG7; we noticed GNLY, NKG7, KLRF1 running differential expression. Cytotoxic NK (CD56-dim).
Rationale DOI: 10.1126/science.abl5197

Set of Labels Description: Displayed cell annotations represent 43 coarse cell type clusters derived using combined manual and automatic annotation using CellTypist.
Annotation Method: both
Algorithm Name: CellTypist
Algorithm Version: v1.7
Algorithm URL: https://github.com/Teichlab/celltypist