Human PBMC atlas - B memory cells

Main

Cell Metadata

B IgA switched memory ITGB1

Full Name: ITGB1+ IgA memory B cell
Closest Ontology Term: IgA memory B cellCL:0000973
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: B cellCL:0000236
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: Cluster with canonical IgA switched memory markers and +ITGB1
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: IGHG1, IGHG2, IGHG3, IGHG4, ITGB1
Canonical Marker Genes: MS4A1, CD27
Rationale: Cluster with canonical IgA switched memory markers and +ITGB1
Rationale DOI: https://doi.org/10.1126/sciimmunol.ady8948 https://doi.org/10.1084/jem.20220342

Set of Labels Description: Cell annotations were generated through iterative hierarchical clustering. Broad lineages were first identified and then recursively subdivided into finer sublineages and sub-sublineages (e.g., T → CD4 T → Effector CD4 T). Clusters were iteratively re-clustered at multiple resolutions, split or merged based on biological evidence, and refined through repeated quality-control steps. Final annotations were determined by consensus of an international group using canonical marker genes, one-vs-all and all-vs-all differential expression analyses, and cluster relationships within the hierarchical framework. Low-quality cells, doublets, and contaminating populations were identified and removed throughout the annotation process; following each round of removal, datasets were reprocessed and re-clustered to improve cluster resolution and biological consistency before subsequent annotation refinement.
Annotation Method: manual

Full Name: ITGB1+ IgA memory B cell
Closest Ontology Term: IgA memory B cellCL:0000973
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: B cellCL:0000236
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: Cluster with canonical IgA switched memory markers and +ITGB1
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: IGHG1, IGHG2, IGHG3, IGHG4, ITGB1
Canonical Marker Genes: MS4A1, CD27
Rationale: Cluster with canonical IgA switched memory markers and +ITGB1
Rationale DOI: https://doi.org/10.1126/sciimmunol.ady8948 https://doi.org/10.1084/jem.20220342

Set of Labels Description: Cell annotations were generated through iterative hierarchical clustering. Broad lineages were first identified and then recursively subdivided into finer sublineages and sub-sublineages (e.g., T → CD4 T → Effector CD4 T). Clusters were iteratively re-clustered at multiple resolutions, split or merged based on biological evidence, and refined through repeated quality-control steps. Final annotations were determined by consensus of an international group using canonical marker genes, one-vs-all and all-vs-all differential expression analyses, and cluster relationships within the hierarchical framework. Low-quality cells, doublets, and contaminating populations were identified and removed throughout the annotation process; following each round of removal, datasets were reprocessed and re-clustered to improve cluster resolution and biological consistency before subsequent annotation refinement.
Annotation Method: manual